It is well recognized that a part of the poisons absorbed by the blood is excreted in the gastro-intestinal tract and produces a certain effect on its mucous membrane. However, systematic histologic experiments concerning these effects are lacking, and especially as regards the differences of effect between grown and very young animals.
From my experiments I expected: (1) that the various kinds of poisons offered would produce different effects on the different regions of the intestinal tract; (2) that the pathologic-anatomic and pathologic-histologic study of these effects would show various results, depending on the kind of poison used; (3) that in such experiments the results obtained would differ to a certain degree in very young animals from those in grown animals.
It is certain that in diseases of the intestinal tract of infants the clinical signs and the pathologic-anatomic findings usually differ from those of the adult. For instance, we
OKUBO N. EXPERIMENTAL RESEARCH ON THE EFFECT ON THE GASTRO-INTESTINAL TRACT OF THE EXCRETION OF POISONS, CONSIDERING THE AGE OF THE ANIMALS. Am J Dis Child. 1918;16(6):376-387. doi:10.1001/archpedi.1918.01910180019002