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July 1920

ACTIVE IMMUNIZATION AGAINST DIPHTHERIA IN A LARGE CHILD-CARING INSTITUTION

Am J Dis Child. 1920;20(1):22-28. doi:10.1001/archpedi.1920.01910250030004
Abstract

During the past few years our ability to detect antitoxin immunity in diphtheria has been greatly simplified by the introduction of the Schick test. Since this test has been shown to be a very accurate measure of the body's antitoxic immunity, we are now able by its use to measure the value of any new form of prophylactic treatment which depends on the production of antitoxin. A new form of preventive treatment is the toxin-antitoxin injection first advocated by Theobald Smith and William H. Park, and first actually employed in human beings by von Behring. During the past five years we have been able to use this active immunization and to control it by means of the Schick test in the Home for Hebrew Infants. This institution is especially adapted for this work, as the same children can be observed and retested for a period of about five years; furthermore,

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