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May 1921


Author Affiliations

From Children's Mercy Hospital.

Am J Dis Child. 1921;21(5):477-483. doi:10.1001/archpedi.1921.01910350064008

There are few subjects about which so much has been written and said, and yet so little is understood as about chorea. Until the etiology of this disease, or symptom, as the case may be, is determined, we can hope for little headway. It is with a desire to add a bit of evidence along such lines that I present this preliminary report of work I am undertaking.

Kowalewsky was probably the first to suggest syphilis as the etiology of chorea. Milian1 then presented two cases with positive Wassermann reactions, and by 1914 he became established in the opinion that all chorea is syphilitic in origin.2 Comby3 challenged this theory, contending that a positive Wassermann reaction is no better evidence in favor of syphilis as the cause of chorea, than a positive tuberculin reaction is that tuberculosis is the cause. Guillian pointed out that the pathology in

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