Since Escherich, in 1898, demonstrated infections of the urinary tract with the colon bacillus in infants and children to be extremely common, the subject has been discussed from almost every point of view. The route by which the infection gains entrance to the urinary tract is yet to be decided, as recently pointed out by Helmholz.1
In looking over the literature for the past twenty years, it is interesting to note that practically nothing new has been added during the past ten years. In 1910, I published an analysis of twenty-five cases,2 the first dating 1901, which included virtually every clinical phase of the disease.
The one characteristic symptom is the sudden onset with high fever, frequently as high as 105 or 106 F. There is often no other symptom and the child does not seem to be "sick" enough to correspond to the degree of fever present,
RAMSEY WR. ACUTE INFECTIONS OF THE URINARY TRACT IN INFANTS AND CHILDREN SUBSIDING WITHOUT THE APPEARANCE OF PUS IN THE URINE. Am J Dis Child. 1922;24(3):218-220. doi:10.1001/archpedi.1922.04120090041007