During the thirty years that have elapsed since attention was drawn to the frequent occurrence of colipyuria in childhood, from infancy and onward, research work has been zealously pursued in an effort to find a remedy for this condition. The many methods of treatment suggested and the numerous medicaments introduced—most of them only to disappear quickly—indicate better than anything else how little success has been attained.
In cases in which there is no indication for surgical measures, such as in concrements to be removed or deformities to be corrected, an effort has generally been made to clear up the infection by urinary disinfectants given by mouth and excreted by the kidneys, or the patient is treated with alkalis administered in large doses, in an endeavor to change the reaction of the urine from acid to alkaline, and thereby eliminate the colon bacillus from the urinary duct. The vaccine treatment has
POULSEN V. THE TREATMENT OF COLIPYURIA IN CHILDREN. Am J Dis Child. 1923;26(1):56–64. doi:10.1001/archpedi.1923.04120130059004