[Skip to Content]
[Skip to Content Landing]
Other Articles
March 1924

STUDIES IN THE URIC ACID METABOLISM OF CHILDREN

Author Affiliations

NEW YORK
From the Pathological Laboratory and the A. Jacobi Division for Children of the Lenox Hill Hospital.

Am J Dis Child. 1924;27(3):243-255. doi:10.1001/archpedi.1924.01920090048006
Abstract

There is, perhaps, no nitrogenous substance in the urine that has been more carefully studied than uric acid. The majority of the investigations concerning the uric acid content of the urine which have been carried out have dealt chiefly with adults. The present report is of a study of the uric acid metabolism in children.

It was believed for a long time that uric acid in mammalian urine was an intermediary product of protein metabolism which was almost completely oxidized by the body to urea. We now know that this point of view is fundamentally incorrect, and that uric acid is derived from the catabolism of the nucleins of both the food and the tissues. As is well known, the nucleins contain nucleic acid, which in turn contains purins. It is the oxidation of the purins that yields uric acid.

The variations in the total daily elimination of uric acid,

First Page Preview View Large
First page PDF preview
First page PDF preview
×