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April 1924

THE ESTIMATION OF THE VOLUME OF BLOOD IN NORMAL INFANTS AND IN INFANTS WITH SEVERE MALNUTRITION

Author Affiliations

NEW YORK
From the pediatric service, New York Nursery and Child's Hospital, and the Department of Pediatrics, Cornell University Medical College.

Am J Dis Child. 1924;27(4):340-351. doi:10.1001/archpedi.1924.01920100045006
Abstract

No study on fluid regulation in the body can be complete without some knowledge of the total amount of circulating fluid. Because of the large quantities of blood hitherto necessary to estimate the blood volume, few determinations have been made in infants. It was primarily with the purpose of obtaining more data on the subject that this investigation was undertaken.

The method used for estimating the volume of blood was a micromodification of the method of Keith, Rowntree, and Geraghty1 as improved by Hooper, Smith, Belt and Whipple.2 A known amount of a nontoxic, slowly diffusible dye is injected into a vein, is allowed to circulate for a few minutes and a specimen of blood withdrawn. By determining the concentration of the dye in the plasma, the plasma volume may be calculated. The total blood volume may be computed from the hematocrit reading.

In normal adults the total

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