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September 1924

THE INTRAVENOUS USE OF MERCUROCHROME-220 SOLUBLE IN THE TREATMENT OF PNEUMONIA IN CHILDREN

Author Affiliations

ATLANTA, GA.
From the Department of Diseases of Children, Emory University.

Am J Dis Child. 1924;28(3):310-321. doi:10.1001/archpedi.1924.04120210047005
Abstract

Several years ago a new drug was introduced by Young, White and Swartz1 for use as a germicide in the genito-urinary tract. Since its introduction this drug, mercurochrome-220 soluble, has found wide fields for employment, both in medicine and in surgery.

Mercurochrome is the sodium salt of dibromoxymercury-fluorescein, made by combining one atom of mercury with one molecule of dibromfluorescein and contains about 26 per cent, mercury. It has been shown that in dilutions of 1: 5,000 it kills Staphylococcus aureus in five minutes and B. coli in fifteen minutes. When given intravenously in doses of 0.005 gm. per kilogram of body weight, the resulting dilution with the blood is approximately 1: 13,000. Dissolved in defibrinated blood in strengths of 1: 8,000 the Streptococcus hemolyticus is killed in forty minutes, and when the dilution is made 1: 16,000 (well above that occurring with ordinary doses used intravenously) it kills

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