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June 1925


Author Affiliations

From the New York Nursery and Child's Hospital, Department of Pediatrics, Cornell University Medical College.

Am J Dis Child. 1925;29(6):773-779. doi:10.1001/archpedi.1925.04120300047007

In diagnosing a case of tuberculosis, it is desirable to have additional aids to the clinical evidence. This is especially true in infants and children in whom it is difficult to obtain subjective symptoms. The present work is an attempt to study the relations between the serum lipolytic activity of patients having tuberculosis and their clinical condition. By lipolytic activity of the serum is meant the power of the serum to convert neutral fat into fatty acids and glycerol.

In 1900. Achard and Clerc1 made studies of the lipolytic power of human blood serum. Later, Gamier2 wrote about the fat splitting activity of the serum of adult patients suffering from tuberculosis. He concluded that chronic tuberculous infiltration of the lung is accompanied by a diminished serum lipase, and considered a persistently low serum lipolytic activity as an indication of a bad prognosis. Kollert and Frisch3 studied the

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