Urobilin excretion in the stools is generally considered one of the few methods at hand of determining the presence or absence of blood destruction in patients in whom the blood count and hemoglobin are low, and in whom it is important to find out whether there is an actual destruction of red cells after they are formed or a lack of production of red cells. Pearce, Krumbhaar and Frazier1 mention it as being one of the valuable methods for determining the state of the hematopoietic system in adults, used in conjunction with smears to determine the presence or absence of regeneration forms and stippled cells, and also in conjunction with fragility tests. It has been used for diagnosis in various kinds of anemia, in splenomegalies, in purpuras and in hemolytic jaundice.
There is considerable variation between the urobilin excretion of adults and of children. Wilbur and Addis found the
MERRITT K. UROBILIN EXCRETION IN CHILDREN WITH ANEMIA. Am J Dis Child. 1925;30(5):667-669. doi:10.1001/archpedi.1925.01920170071006