January 1926


Am J Dis Child. 1926;31(1):102-103. doi:10.1001/archpedi.1926.04130010109014

To the Editor:—In a recent paper, read before the American Pediatric Society and published in the American Journal of Diseases of Children,1 considerable space was devoted to a discussion of results reported by my co-workers and myself2 on the nature of fever in new-born infants. We found (1) that the serum protein concentration, determined refractometrically, is considerably higher in febrile than in afebrile new-born infants, indicating, probably, a loss of water from the serum; (2) that the administration of fluids by mouth causes a simultaneous fall in temperature and blood concentration as measured by the change in serum protein concentration and red blood cells. From these findings we conclude that fever in new-born infants is due to dehydration.

Sherman objects to our conclusions on the basis that "this method (the refractometric) assumes that the serum proteins are present in the blood in the same concentration normally and

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