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April 1926

PLASMA CHLORIDES IN ACUTE INTESTINAL INTOXICATION OF CHILDREN

Author Affiliations

TORONTO, CANADA
From the wards of the Hospital for Sick Children, and the research laboratories of the Sub-Department of Pediatrics, University of Toronto, under the direction of Alan Brown, M.B.

Am J Dis Child. 1926;31(4):514-519. doi:10.1001/archpedi.1926.04130040057009
Abstract

In recent years much interest and varying degrees of importance have been attached to the chloride content of the blood plasma.1 Hypochloremia has been noted in a number of such unrelated clinical conditions as severe superficial burns, pneumonia, war-gas poisoning, the pernicious vomiting of pregnancy and high intestinal obstruction.2 Closer study reveals the fact that in spite of their diverse pathology, these conditions all have one of two factors in common. There is either a circulating toxin of a split protein nature as in intestinal obstruction3 and burns,4 or there is a rapid and severe loss of fluids as in war-gas poisoning, pernicious vomiting and pneumonia. In some instances there is a combination of the two. It was therefore thought that a study of the chlorides in acute intestinal intoxication in which fluid loss and a split protein intoxication5 were both present would be of

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