During the past two decades, iodine in its relation to the thyroid gland and to the prevention and cure of goiter has been a subject of renewed interest and investigation. The work, especially that of Marine and his associates,1 has demonstrated that simple goiter can be prevented, and has stimulated the undertaking of thyroid surveys in many parts of the world.
Marine2 states that goiter is a term used to describe all thyroid enlargements in animals as well as in man. Although the ultimate cause of thyroid enlargement is still unknown, it is immediately dependent on a relative or absolute deficiency of iodine in the thyroid gland—iodine hunger. This hunger exists if the iodine content of the thyroid gland falls below one-tenth of 1 per cent (0.1 per cent),3 and is made evident by the symptom of a slight compensatory swelling or hyperplasia of the gland,
COHEN F. GOITER IN CHILDREN IN NEW YORK CITYTHYROID SURVEY OF 11,084 SCHOOL GIRLS AND 783 SCHOOL BOYS. Am J Dis Child. 1926;31(5):676–692. doi:10.1001/archpedi.1926.04130050076007