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The monograph of 104 pages contains the results of the author's studies on the protein and mineral metabolism of infants during fever. In the first twenty-five pages, he reviews the meager literature. Following Naunyn, the older observers ascribe the rise in protein metabolism occurring in fever to a toxic destruction of protoplasm. In accord with Krehl, more recent observers attribute it to a disturbance of central nervous origin. Animal experiments have demonstrated the existence of regulating centers in the brain which control the total metabolism (body temperature) and also the metabolism of protein, fat and carbohydrate (the latter being known since the time of Claude Bernard). The author cites the rather unconvincing evidence for this conception, and concludes that the mechanism controlling protein metabolism is as follows: A parasympathetic center located in the midbrain retards the metabolism of protein. This center corresponds to that portion of the heat regulating center
THE METABOLISM OF CHILDREN DURING FEVER.. Am J Dis Child. 1926;32(2):321-322. doi:10.1001/archpedi.1926.04130080161014