These observations were undertaken as a part of a study of some forms of hemolytic anemia, and were prompted especially by the receipt from Dr. Grulee of a film showing, in a case diagnosed as sickle cell anemia, skull changes similar to those described by us1 last year.
Our hospital clientele includes many negroes, and for some ten months past the blood of all colored children admitted has been examined for sickle cells, and for evidence of any characteristic anemia in patients whose blood shows these forms. So far as possible, the blood of the parents and other relatives has been examined also, and inquiries have been made as to a history of any peculiar symptoms suggestive of anemia, and of leg ulcers.
In all, the blood of 400 colored hospital patients has been examined, and sickle cells have been found in 30, or 7.5 per cent. This is
COOLEY TB, LEE P. THE SICKLE CELL PHENOMENON. Am J Dis Child. 1926;32(3):334-340. doi:10.1001/archpedi.1926.04130090011002