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May 1927

AGGLUTINATION REACTIONS IN RABBITS FOLLOWING ORAL VACCINATION WITH BACILLUS DYSENTERIAE

Author Affiliations

BALTIMORE
From the Department of Pediatrics, Johns Hopkins University Medical Department.

Am J Dis Child. 1927;33(5):714-716. doi:10.1001/archpedi.1927.04130170012003
Abstract

Considerable work has been done in recent years on protection against bacillary dysentery by the oral administration of dysentery vaccines. Enlows1 gives a review of the literature, much of it indicating that some immunity at least is afforded by the ingestion of killed dysentery bacilli. The greater part of the work has been done with the Shiga type of organism, as it is the chief type causing serious dysentery in adults. In children in this country, however, the Shiga bacillus is found only in a small percentage of the cases as compared with those caused by the several strains of the Flexner dysentery organism. It was suggested to us that before any attempt was made to determine the efficacy of feeding a killed Flexner vaccine to children its ability to produce antibodies in rabbits should be tested by feeding them the vaccine. This work was therefore undertaken to determine,

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