In connection with a study of a group of thirty-nine children suffering from enuresis, the observation was made that in a certain percentage of the more persistent cases the concentration of the urine was definitely and constantly higher during the day than during the night. The occurrence of a reversal of the usual concentration of the urine in children suffering from this condition apparently has not been observed to date and consequently was considered of sufficient interest and importance to justify reporting.
The observations were made on thirty-nine patients at the university dispensary and are recorded in tables 1 and 2. Each child in the series was carefully examined to avoid including those suffering from pyelocystitis or other diseases presenting symptoms referable to the genitourinary system. Twenty-four hour samples of urine were collected from each patient, the day and night specimens being kept separate. The specimens were carefully measured and
FRIEDELL A. A REVERSAL OF THE NORMAL CONCENTRATION OF THE URINE IN CHILDREN HAVING ENURESIS. Am J Dis Child. 1927;33(5):717–721. doi:10.1001/archpedi.1927.04130170015004