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August 1927

INORGANIC BLOOD PHOSPHATESTUDIES OF RATS ON RACHITIC AND NONRACHITIC DIETS

Author Affiliations

CHICAGO
From the Department of Pharmacology and Therapeutics, University of Illinois College of Medicine.

Am J Dis Child. 1927;34(2):187-197. doi:10.1001/archpedi.1927.04130200031005
Abstract

In connection with our studies of the antirachitic factor in cod liver oil and irradiated cholesterol, we determined the inorganic blood phosphate of rats, hoping that this information could be used, in addition to roentgenograms and histologic examination, as an aid in the diagnosis of the rachitic condition. The first determinations were made on rats about 6 months old, which had been obtained originally from Doure-Doure. At the age of from 3 to 4 weeks, they were placed on the McCollum rachitic diet 3143.1 To the diet of one group of these rats was added 0.2 per cent of irradiated cholesterol and to another 0.2 per cent of nonirridiated cholesterol. Still another group of animals on diet 3143 was irradiated daily. The rats on the rachitic diet alone or on the rachitic diet plus nonirradiated cholesterol, developed rickets much less rapidly than young rats which we later bred in

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