Serious cardiovascular disease, chiefly affecting the aorta, is a well known late complication of acquired syphilis. The rôle played by congenital syphilis in the production of cardiovascular disease is much less known and has received but scant attention in the literature. The desire to determine more definitely what immediate and remote effects congenital syphilis may have on the heart and aorta has stimulated the study presented herewith.
REVIEW OF LITERATURE
A. MYOCARDIAL CHANGES
In a book issued in 1885 by J. Parrot1 "La syphilis héréditaire et le rachitis," reference is made to Rosen who in 1860 mentioned gummas of the heart in congenital syphilis. M. Wagner2 observed myocarditis in a new-born infant whose mother had signs of syphilis. Virchow3 found interstitial myocarditis and white hepatization in an 8 months' fetus. The mother undoubtedly had syphilis, and she had aborted four times previously. In 1875, Coupland4 presented
MATUSOFF I, WHITE PD. THE HEART AND BLOOD VESSELS IN CONGENITAL SYPHILIS. Am J Dis Child. 1927;34(3):390-403. doi:10.1001/archpedi.1927.04130210065007