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February 1928


Author Affiliations

From the Department of Pediatrics, Western Reserve University, and the Division of Contagious Diseases, Cleveland City Hospital, Cleveland.

Am J Dis Child. 1928;35(2):186-192. doi:10.1001/archpedi.1928.01920200018002

Many physicians have reported high percentages of successful vaccinations by the intradermal method (Starkey,1 Berney,2 Twyman,3 Wright4 and Simko5). Leiner and Kundrawitz6 vaccinated fifty children with 0.1 cc. of a 1:100 dilution of vaccine and obtained positive and feverless reactions in thirty-nine, no reactions in five and atypical reactions in six. Singer7 also claims that fever associated with intradermal vaccination is rare or of short duration, the reactions milder and the resultant scars less definite. Many authors (Kovacs,8 Frankenstein,9 Gettinger10 and Hoffman11) believe that there is a decrease in secondary infections. Three hundred and twenty-one of Twyman's 397 patients, or 80.9 per cent, had positive reactions. Wright vaccinated intradermally 227 patients who previously had been vaccinated unsuccessfully as often as from two to eight times, with 160 successful vaccinations (70.4 per cent). These patients were vaccinated concurrently with the

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