For a number of years, much interest has attached to the general problem of dehydration and especially to the changes that occur in the blood with undue loss of water from the body. As a review by Marriott1 has appeared recently, an attempt is not made here to recapitulate the early literature except so far as the work of previous investigation bears directly on the present subject.
In approaching this problem in infants and children, one is more or less limited to the use of physical methods, since accurate chemical analyses of the several components usually require quantities of blood too great to be withdrawn with safety from the dehydrated infant. Also, as data obtained by physicochemical methods have already been reported by Salge,2 Lust,3 Reiss,4 and Berend and Tezner,5 it seemed of first importance to correlate the facts revealed by the physicochemical examination of
DARROW DC, BUCKMAN TE. THE VOLUME OF THE BLOODII. THE VOLUME OF THE BLOOD AND CONCENTRATION OF CRYSTALLOIDS AND ELECTROLYTES IN DEHYDRATION AND EDEMA. Am J Dis Child. 1928;36(2):248–267. doi:10.1001/archpedi.1928.01920260056002