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September 1928


Am J Dis Child. 1928;36(3):434-444. doi:10.1001/archpedi.1928.01920270011002

During 1905 and 1906, Heerfordt had the opportunity of observing three patients in the Copenhagen City Hospital, each of whom presented so similar and so striking a clinical picture that in 1909 he ventured to describe the condition as a hitherto unrecognized clinical entity. There were three essential and outstanding features in these cases: enlargement of the parotid glands lasting several months and thus running a relatively chronic course in contrast with the acute swelling in epidemic parotitis; an ocular inflammation involving the uveal tract, and a long continued fever of low degree corresponding with the subchronic course of both the iridocyclitis and the parotitis. In two of the three patients there were cerebrospinal paralyses. For this symptom-complex, Heerfordt proposed the descriptive title febris uveoparotidea subchronica, thus emphasizing the three chief characteristics and the course of the disorder.

Heerfordt's1 communication was followed by numerous case reports of a similar

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