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Progress in Pediatrics
October 1928


Am J Dis Child. 1928;36(4):799-818. doi:10.1001/archpedi.1928.01920280150015

Does the nature of the cerebrospinal fluid differ with the age of the person during health and disease? The only way to ascertain this would be to perform a series of punctures on the same person at intervals from birth to old age, which would be an unjustifiable procedure. That variations in the cerebrospinal fluid do occur with age may be inferred from an occasional reference in the literature. Bernhard,1 for instance, found the uric acid content of cerebrospinal fluid to be higher in children than in adults. It has been noted by Roberts2 that the cerebrospinal fluid in the normal new-born infant is yellow, while in the older child it is colorless.

I have observed that in the new-born child the rate of flow of fluid through the spinal puncture needle is less than that of older infants or children. It is from such casual observations that

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