At the Babies' Hospital, interest in sickle cell anemia dates from a case seen in December, 1925.
REPORT OF CASES
Case 1.—A colored girl, aged 3 years and 11 months, was admitted to the hospital with pain and stiffness in the joints of both elbows. An examination of the blood revealed the fact that 12 per cent of the red cells were sickle-shaped. She had been born at term, weighing 6 pounds (2.7 Kg.), and was first seen in the outpatient department at the age of 9 months, with the complaint of cough and sweating. When seen again at the age of 3 years, she was anemic; the spleen was hard and palpable, and the liver reached the costal margin. There was a yellowish-green discoloration of the sclerae, and the cervical glands were enlarged. Three months later, she complained of abdominal pain and pain in both arms, and was admitted
WOLLSTEIN M, KREIDEL KV. SICKLE CELL ANEMIA. Am J Dis Child. 1928;36(5):998-1011. doi:10.1001/archpedi.1928.01920290126008