The value of diphtheria toxoid (anatoxin-Ramon), the modified toxin of diphtheria, in active immunization of man has been firmly established since Glenny's experiments with animals and Ramon's clinical demonstration of its efficiency. Its use on a broad scale has grown, particularly in France and in Canada. The lack of any extensive trial of toxoid in this country is, to a large extent, attributable to the strong foothold that prophylaxis with toxin-antitoxin has gained, following the impetus given to its popularization by Park and his collaborators. Through their laudable efforts, a marked reduction in the incidence of diphtheria has been effected in this country.
The preference that toxoid has received in other countries within the last few years is the result of certain important advantages that have been recognized in the use of this material. These advantages have been emphasized by Ramon and Helie1 in a recent report to the
WEINFELD GF, COOPERSTOCK M. COMPARATIVE EFFECTS OF DIPHTHERIA TOXOID AND TOXIN-ANTITOXIN AS IMMUNIZING AGENTS. Am J Dis Child. 1929;38(1):35–46. doi:10.1001/archpedi.1929.01930070047005