On Dec. 7, 1928, Charles M., a Greek boy, aged 4 years, was brought to the outpatient department of the Children's Hospital because of anemia, enlarged spleen and jaundice.
The present illness, which had been noticed for more than a year, began with lassitude and anorexia. Slight jaundice was observed almost from the beginning, with no increase in intensity. The stools had been normal in color, and the urine possibly darker than before. There had been some loss in weight. A splenic tumor had been noticed for some months. There had been no vomiting and no hemorrhages from any part. The illness had not been severe enough to require putting the child to bed, or to keep him from play.
The history was essentially unimportant. The patient had been apparently normal in infancy, and had developed well, except for poor teeth. Measles had been the only acute illness. The tonsils
COOLEY TB, LEE P. SICKLE CELL ANEMIA IN A GREEK FAMILY. Am J Dis Child. 1929;38(1):103–106. doi:10.1001/archpedi.1929.01930070115014