Since Gabritschewsky, in 1907, proposed the use of a vaccine made of the culture fluid of streptococci to secure an immunization against scarlet fever, much effort has been expended and various types of immunizing agents have been produced, each numbering among its adherents many investigators ready to produce figures and case reports of considerable proportions; this induced an enthusiasm which has undoubtedly given the incentive to immunize large numbers of persons against this disease. Before proceeding with my report concerning immunization by toxoid, the material for which was furnished by Dr. Donald Fraser of the Connaught Laboratories, University of Toronto, it may be well to digress with a cursory review of the literature and some figures as to the relative values of the various methods of immunization in use at this time.
When Gabritschewsky, with his first dose of 0.5 cc. of vaccine, produced a rash similar to that of
McMAHON HO. SCARLET FEVER TOXOID. Am J Dis Child. 1930;39(1):66-69. doi:10.1001/archpedi.1930.01930130078007