Since the discovery of urobilin, in 1868, by Jaffe, urobilinuria has been observed in a wide variety of clinical conditions. Although numerous hypotheses have been proposed to explain the origin of urobilin in both the normal and the diseased organism, information of positive value was unavailable until within the last few years. Peyton Rous and his collaborators have approached anew the entire problem of the physiology and pathology of urobilin. Their work includes the elaboration of a quantitative method for determining urobilinuria, described by Elman and McMaster.1 This method possesses the two essential requisites for a clinical laboratory procedure, simplicity and accuracy, and it was adopted for the studies reported herein.
In a series of articles, Elman and McMaster presented abundant evidence to support the view that in the uninfected animal the intestinal tract is the only site of origin of urobilin. Urobilinuria is an expression of the inability
EDELMAN MH, HALPERN L, KILLIAN JA. UROBILINURIAITS PROGNOSTIC VALUE IN CHILDREN WITH HEART DISEASE. Am J Dis Child. 1930;39(4):711–728. doi:10.1001/archpedi.1930.01930160029004