Phenylethylhydantoin was introduced under the name "nirvanol"1 in 1916 as a sedative. The frequent occurrence of severe symptoms such as rash or fever led many authors2 to warn against its use. In 1919, Roeder3 recommended phenylethylhydantoin in the treatment for chorea minor.
The reports4 were so encouraging that we undertook a study of the action of this drug in a series of cases of chorea. Since chorea is a highly variable disease, no therapeutic study is convincing unless a fairly large number of cases is included, and unless comparison is made with cases in the same series in which the patients were treated by other methods. So far as we are aware, this has not been done previously. This report is based on the study of twenty-five cases; as the children entered the hospital, every other one was treated with phenylethylhydantoin. The dose for younger children
RAY HH, CUNNINGHAM JS. PHENYLETHYLHYDANTOIN IN THE TREATMENT OF SYDENHAM'S CHOREA. Am J Dis Child. 1930;39(6):1205-1213. doi:10.1001/archpedi.1930.01930180055005