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A brief though interesting historical review of the different conceptions of neurasthenia leads to the conclusion that neurasthenia cannot be looked on as a disease entity. Different types with their different syndromes have to be distinguished. With regard to the pathogenesis, the biologic foundation of the different types of neurasthenia is sought in congenital and acquired functional disorders within the neurohormonal systems. The investigations of the author led to the distinction of two main clinical types "neurasthenia apathica" and "neurasthenia irritative." The first of these is characterized by deadly fatigue, weakness, dyspepsia, lack of concentration and hypotension. The main desire is immobility and rest. The irritative type is dynamic, and, in contrast to the apathic type, the patients are vociferous about their multitudinous ailments. Sexual disorders are common, as is a tendency to hypertension. It is recognized, of course, that the symptomatology can vary considerably. In their purer forms these
DIE REVISION DER NEURASTHENIEFRAGE. DIE KLINISCHE UND PATHOGENETISCHE NEUORIENTIORUNG ZUM NEUROSTHENIE PROBLEM.. Am J Dis Child. 1930;40(1):221. doi:10.1001/archpedi.1930.01940010232019