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November 1930

RAPIDITY OF IMMUNIZATION WITH DIPHTHERIA TOXOID

Author Affiliations

ANN ARBOR, MICH.; RAVINIA, ILL.
From the Department of Pediatrics and Infectious Diseases, University of Michigan.

Am J Dis Child. 1930;40(5):1035-1038. doi:10.1001/archpedi.1930.01940050097011
Abstract

In a previous report,1 we submitted our results with the use of diphtheria toxoid, concluding that this material has a high immunizing value, and that, by virtue of certain important advantages that it possesses, it recommends itself as an ideal agent in vaccination against diphtheria. Recent additional reports in this country2 have added to the accumulating evidence in support of this contention. It is our purpose here simply to record observations on the rapidity of production of the immunity with diphtheria toxoid under comparatively minimal requirements.

Rapidity of Immunization with Two Injections (1 Cc. Each) of Diphtheria Toxoid Group I II III Number of Subjects with Positive Reactions to Schick Test 50 44 65 Number of Weeks Between Injections Results of Schick Retcst Number of Weeks After Second Injection Negative Schick Reactions 29 (58.0%) 35 (79.5%) 60 (92.3%)

To determine the rapidity with which immunity is obtained following

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