In dealing with the so-called mongolian idiot one is struck by the similarity in physical features and general conduct. These patients run so true to type that children of the same age often resemble one another as much as sisters and brothers do, even though they are of different races. This marked similarity in physical and mental characteristics has recently attracted the attention of the endocrinologist, who expects to find the answer to this in a dysfunction of the endocrine glands. It is thought that the chief functional disturbance lies in the pituitary gland. Working on this hypothesis, Timme1 obtained some encouraging results from treatment with a combination of thyroid and pituitary extracts.
Sugar tolerance curves in endocrine dysfunctions have been the subject of a great deal of investigation during the past fifteen years. Hamman and Hirschman2 showed a low tolerance in hyperfunction of the thyroid and pituitary
O'LEARY WD. CARBOHYDRATE METABOLISM IN MONGOLIAN IDIOTS AS EVIDENCE OF ENDOCRINE DYSFUNCTION. Am J Dis Child. 1931;41(3):544–551. doi:10.1001/archpedi.1931.01940090061007