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Case Reports
April 1931

FATAL ACUTE LYMPHOBLASTIC LEUKEMIA WITH GREAT ENLARGEMENT OF THE KIDNEYS IN AN INFANT THREE WEEKS OLD

Author Affiliations

ST. LOUIS
From the Departments of Pediatrics and Pathology, Washington University School of Medicine, and the St. Louis Children's Hospital.

Am J Dis Child. 1931;41(4):866-870. doi:10.1001/archpedi.1931.01940100122013
Abstract

The literature of the past fifteen years contains a number of reports of cases of lymphatic leukemia having their onset at birth or during the first few weeks of life. But no report has been encountered in which such extraordinary enlargement of the kidneys due to lymphocytic invasion has been observed.

In a study of 100 cases of leukemia in childhood (91 from the literature, 9 from his own practice), Ramsay1 noted that all were in children under 8 years of age, that 70 per cent were of the lymphatic type, and that twice as many cases occurred during the first four years of life as during the second. Certain cases seemed to date from birth. In none of these cases was it found that the mother suffered from leukemia. In three of the lymphocytic cases the kidneys were reported as large and easily palpated. All three of these

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