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June 1931

PREPARATION OF A SOLUTION OF SODIUM BICARBONATE AND SODIUM CHLORIDE FOR HYPODERMOCLYSIS

Author Affiliations

NEW HAVEN, CONN.
From the Department of Pediatrics, Yale University School of Medicine, and the Pediatric Service of the New Haven Hospital and Dispensary.

Am J Dis Child. 1931;41(6):1347-1352. doi:10.1001/archpedi.1931.01940120084009
Abstract

The treatment for dehydration and acidosis plays an important rôle in the practice of all branches of medicine, and in this paper we describe a solution suitable for subcutaneous injection in these conditions. The type of fluid injected subcutaneously in the treatment for dehydration will vary with one's conception of what is taking place, and it does not seem out of place to discuss the pathologic physiology of dehydration as it seems to concern the methods of treatment.

The conception of Marriott1 that anhydremia plays the chief rôle in producing the symptoms of dehydration is well founded. Darrow and Buckman2 found that about one third of the volume of plasma is lost in severe dehydration; this loss of volume is greater proportionately than the loss of body weight. This observation seems to point to the fact that water is not lost equally from all parts of the body,

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