While the intrathecal administration of serum in meningococcus meningitis has been fairly satisfactory as generally practiced, it has been hoped that a method might be devised that would provide a larger initial dosage and a wider distribution of serum. In the spring of 1926, I attempted to do this by introducing serum into the spinal subarachnoid space and into the ventricles, following this immediately by drainage from the cisterna magna until the flow from the needle practically stopped. In the three patients I treated in this manner1 the results were very gratifying. Each patient received two such treatments thirty-six hours apart, and no more serum was required to keep the fluid free from organisms after the third day. Early and complete recovery occurred.
In February, 1930, I removed a complicating obstruction of the aqueduct of Sylvius2 by means of injecting serum into the cisterna magna and withdrawing fluid
LYON GM. SERUM THERAPY IN MENINGOCOCCUS MENINGITIS. Am J Dis Child. 1932;43(3):572-576. doi:10.1001/archpedi.1932.01950030042006