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Case Reports
April 1932

PREMATURE SEXUAL DEVELOPMENT IN CHILDREN DUE TO MALIGNANT OVARIAN TUMORSWITH SPECIAL REFERENCE TO HORMONAL STUDIES AND AFTER-TREATMENT

Author Affiliations

NEW YORK
From the Gynecological Service and the Division of Laboratories, Mount Sinai Hospital.

Am J Dis Child. 1932;43(4):942-946. doi:10.1001/archpedi.1932.01950040142011
Abstract

A considerable number of malignant tumors of the ovary in young children have been described. A small number are accompanied by premature sexual development, which, due to the fact that recession of prematurity takes place after the removal of the tumor, must be ascribed to the influence of the ovarian growth. Not every tumor of the ovary in children, however, irrespective of whether it is malignant or benign, produces pubertas praecox. On the other hand, activation has been noted with various histologic types of malignancy. In my own experience both a carcinoma and a teratoma of the ovary proved to be the underlying cause of prematurity. In one other case in which a carcinoma of the ovary was present without premature sex development, considerable female sex hormone was noted in the urine, a finding that I have never observed in normal children. An excess of female sex hormone in the

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