Since Burn's original description in 1823, chloroma has been the subject of periodic reviews, the more important of which include those of Dock and Warthin,1 Lehndorff,2 Burgess,3 Brannan4 and Washburn.5 Washburn collected 162 cases of chloroma between 1823 and 1929. The earlier observers considered the disease to be lymphogenous, but since the advent of the oxydase reaction most investigators have come to regard it as being myelogenous. Washburn did not feel that it was possible to deny the existence of a lymphoid type. Brannan, however, classed chloroma as "some variety or form of myelogenous leukemia," and discounted entirely the probability of the occurrence of the lymphatic type of the disease. Moreover, Brannan concluded that the aleukemic form of chloroma was exceedingly rare.
The following case of aleukemic chloroma was considered sufficiently unusual to warrant its publication.
History.—A white girl, aged 2 years,
SWANSON LA. ALEUKEMIC, MYELOGENOUS CHLOROMA. Am J Dis Child. 1932;44(1):140-145. doi:10.1001/archpedi.1932.01950080150013