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Sandro Botticelli, more properly, Alessandro di Mariano dei Filipepi (1444-1510), figures in his Madonna and Child with the two Saint Johns, reproduced here, now in Berlin, a case of multiple arthritis in the hands of the Child and also in those of the Virgin. The changes are most marked in the second joints. Changes are also seen in the fingers of the Child in the Madonna del Magnificat, while the Child in the Madonna del Melagrana shows one joint which could well be a tuberculous condition, although it may be due to the foreshortening in the drawing. The Madonna and the Child in the Poldo-Pezzoli Museum in Milan also shows joint changes, while none are noted in the Madonna and Child and St. John, the Mystic Nativity, Madonna and Child with Six Saints, Madonna and Child with Angel and Primavera. These may be studied in the Medici Society reproductions by
RUHRÄH J. MULTIPLE ARTHRITIS. Am J Dis Child. 1932;44(1):185. doi:10.1001/archpedi.1932.01950080195021