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In spite of the general conception that the etiology of paroxysmal hemoglobinuria lies in syphilis, no applicable treatment has yet been discovered. It is obvious that some antisyphilitic remedies, e. g., arsphenamine, mercury and potassium iodide, exert a curative action on hemoglobinuria to a certain extent, but several years of continuous administration are required, and even then complete convalescence may not be assured. In the clinic of the Manchuria Medical College, a few years ago, a child recovered from paroxysmal hemoglobinuria although the Wassermann test remained positive after more than a year's treatment by inunctions of mercurial ointment, injections of neoarsphenamine and oral antisyphilitic therapy.
Recently, inoculation with Plasmodium malariae has been in common use in the treatment for syphilitic diseases of the nervous system, and the same method has been adopted in the treatment for hemoglobinuria, but to the present time there is no literature regarding the success of
INAMORI S. PAROXYSMAL HEMOGLOBINURIA CURED BY INOCULATION OF SPIROCHAETA MORSUS MURIS. Am J Dis Child. 1932;44(2):379–382. doi:10.1001/archpedi.1932.01950090117012