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February 1933

EXCRETION OF XYLOSE AS A MEASURE OF RENAL FUNCTION IN CHILDREN

Author Affiliations

NEW YORK
From the Chemical Laboratory of the Beth Israel Hospital.

Am J Dis Child. 1933;45(2):271-278. doi:10.1001/archpedi.1933.01950150044003
Abstract

The elimination through the kidney of a fixed proportion of ingested or parenterally administered pentose sugars, combined with the extremely low threshold of the kidney membrane for these sugars, would seem to indicate their use as a delicate measure of renal function. Up to this time, such a use has not been feasible owing to the extremely high cost, but the recent development of a method for the cheap production of xylose has rendered that substance available for this purpose. One thus is enabled to judge the functional power of the kidney by a simple quantitative determination of the reducing-power of the urine two hours after ingestion. Somogyi's1 simple method for the determination of a nonfermentable reducing substance in the blood in the presence of dextrose by the substitution of a yeast suspension for the water used in the Folin-Wu tungstic acid precipitation in the determination of the blood

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