This study of rheumatism has been pursued for several years and in two large pediatric clinics, that of Washington University, St. Louis, and that of the University of Toronto, Canada. Five hundred families with rheumatic members were investigated; this represented more than eight hundred rheumatic persons in the immediate family circles. This was necessarily largely a study of rheumatism as a familial disease, and it was felt that the value of such observations lay not only in the considerable number of families represented, but in the comparison by one observer of rheumatism in two widely differing communities.
By the methods used it was hoped to show the relative importance of heredity and constitution contrasted with infectivity as factors in the occurrence of rheumatism.
In the two clinics the methods of obtaining data were similar. The mother of every rheumatic child examined was questioned as to the occurrence of rheumatism in
IRVINE-JONES E. ACUTE RHEUMATISM AS A FAMILIAL DISEASE. Am J Dis Child. 1933;45(6):1184-1195. doi:10.1001/archpedi.1933.01950190026002