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The etiology and mechanism of acidosis are discussed from the theoretical point of view, with special regard to the ideas of Chabanier and Lobo-Onell. It is claimed that the most reliable index of acidosis is the ratio between the chlorides of the erythrocytes and the chlorides of the plasma. When the ratio is over 0.5, acidosis is indicated and sodium bicarbonate solution is administered. Several cases are cited to show the value of this ratio and its application in determining the therapeutic measures to be instituted. The author also discusses the physiopathology of acute renal insufficiency as it occurs in infants from excessive vomiting or diarrhea. The impaired renal function is attributed to an abnormal excess or decrease in tissue chlorides. The determination of the chlorides of the red blood cells furnishes the information necessary for proper therapy. If the chlorides are high, sodium bicarbonate solution is given. If the
L'acidose et l'insuffisance rénale aiguë chez le nourrisson.. Am J Dis Child. 1933;46(2):466. doi:10.1001/archpedi.1933.01960020229023