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November 1933

CHANGES IN COMPOSITION OF FLUIDS INJECTED INTO THE PERITONEAL CAVITY

Author Affiliations

NEW HAVEN, CONN.
From the Department of Pediatrics, Yale University School of Medicine.

Am J Dis Child. 1933;46(5_PART_I):1015-1026. doi:10.1001/archpedi.1933.01960050077008
Abstract

The injection of various isotonic solutions into extracellular spaces has been practiced for years. The mechanism of the absorption of fluids from the peritoneum has been studied in considerable detail by physiologists. This work establishes the fact that the peritoneum acts like a semipermeable membrane which allows fluid in the peritoneum to come into osmotic equilibrium with blood plasma. However, previous work has not determined how far changes in the concentration of the individual ions takes place in establishing equilibrium between a fluid in the abdominal cavity and blood plasma. Osmotic effects have usually been spoken of in terms of total osmotic pressure, whereas interstitial or peritoneal fluid is in an equilibrium with cellular fluid and blood plasma which is expressed in a delicate balance with each ion fixed within a fairly narrow range of concentration. The following work was undertaken to study the changes taking place in individual ions

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