Granulocytopenia or agranulocytosis, the syndrome first described in detail by Schultz in 1922 under the name of agranulocytic angina, was originally regarded as a condition encountered in women of middle age. In the intervening years, however, it has also been reported as occurring in elderly persons, in men, and, infrequently, in children.
While the literature concerning agranulocytopenia has grown rapidly since 1922, reports of the occurrence of this condition in children are relatively uncommon.
Kato and Vorwald,1 reporting a case in a child aged 5 years, list twelve references to cases reported in childhood, the authenticity of some of which, however, they question because of the symptomatology described.
Among the more recent reports is that of Friedman and Smith2 in which the patient was a girl aged 2 years, and that of Empey and Proescher.3
As it appears that this condition is uncommon, if not rare, in
KILDUFFE RA, NICKMAN EH. AGRANULOCYTIC SYNDROME IN AN INFANT TWENTY-THREE MONTHS OLD, WITH AUTOPSY. Am J Dis Child. 1934;47(5):1065-1069. doi:10.1001/archpedi.1934.01960120123009