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December 1934


Author Affiliations

From the department of pediatrics, Manchuria Medical College.

Am J Dis Child. 1934;48(6):1193-1200. doi:10.1001/archpedi.1934.01960190013002

No definite theory had been established as to the cause of the leukocytosis and lymphocytosis which accompany whooping cough until several years ago Fukushima,1 by a chemical analysis, proved that the Bordet-Gengou bacillus contains abundance of fat and lipoid which if injected into animals cause leukocytosis and lymphocytosis. Sauer and Hambrecht2 also proved the appearance of a similar blood picture in experimental whooping cough in monkeys infected with the Bordet-Gengou bacillus. These facts lead us to assume that the leukocytosis and lymphocytosis which accompany whooping cough are merely a biologic reaction of the organism caused by infection with pertussis bacilli.

As a result of a recent experiment in which we infected young monkeys and puppies with Bordet-Gengou bacilli and made a clinical and pathologico-anatomic study as well as differential counts of the leukocytes, it was ascertained that the blood picture mentioned would appear not only in monkeys but

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