No definite theory had been established as to the cause of the leukocytosis and lymphocytosis which accompany whooping cough until several years ago Fukushima,1 by a chemical analysis, proved that the Bordet-Gengou bacillus contains abundance of fat and lipoid which if injected into animals cause leukocytosis and lymphocytosis. Sauer and Hambrecht2 also proved the appearance of a similar blood picture in experimental whooping cough in monkeys infected with the Bordet-Gengou bacillus. These facts lead us to assume that the leukocytosis and lymphocytosis which accompany whooping cough are merely a biologic reaction of the organism caused by infection with pertussis bacilli.
As a result of a recent experiment in which we infected young monkeys and puppies with Bordet-Gengou bacilli and made a clinical and pathologico-anatomic study as well as differential counts of the leukocytes, it was ascertained that the blood picture mentioned would appear not only in monkeys but
INABA I, INAMORI S. BLOOD PICTURE IN EXPERIMENTAL WHOOPING COUGH. Am J Dis Child. 1934;48(6):1193-1200. doi:10.1001/archpedi.1934.01960190013002