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March 1935

INFLUENCE OF ACUTE INFECTION AND ARTIFICIAL FEVER ON THE PLASMA LIPIDS

Author Affiliations

MINNEAPOLIS
From the Department of Pediatrics, the University of Minnesota.

Am J Dis Child. 1935;49(3):658-671. doi:10.1001/archpedi.1935.01970030104009
Abstract

The chance observation of a precipitous drop in the plasma lecithin values of several epileptic patients in whom there developed acute infections during studies on the blood lipids suggested the investigation of the various lipid fractions of the blood plasma in acute infections and in artificially induced fever. In a previous study1 we presented the results in a preliminary series of cases of various acute infections. Not only the plasma lecithin but the plasma cholesterol and fatty acids were determined. In every case, at the height of the disease there was a definite lowering of the plasma lecithin and cholesterol. The values became subnormal, but they arose again during convalescence, approaching or reaching normal. Changes in the total fatty acid values paralleled those for the lecithin and the cholesterol in most instances.

Although the literature revealed that the plasma cholesterol values had previously been found to be lowered in

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