The purpose of this study was to determine whether the skin is capable of absorbing vitamin D in sufficient amounts to prevent and to cure experimental rickets.
A study of the literature shows a paucity of available information as regards the absorption of vitamin D through the skin. In 1926, Price1 mentioned that vitamin D may be absorbed directly through the skin, but he offered no experimental proof. Hume, Lucas and Smith,2 in 1927, were able to protect rats and rabbits against rickets by inunction with irradiated impure cholesterol. Moncorps et al3 found that the absorption through the skin of large doses of irradiated ergosterol was followed by calcification of the aorta.
Rickets has previously been prevented and cured in one of two ways: (1) by the feeding of cod liver oil or of viosterol, or (2) by irradiation of the skin with the ultraviolet rays from
ASTROWE PS, MORGEN RA. DERMAL ABSORPTION OF VITAMIN D. Am J Dis Child. 1935;49(4):912–922. doi:10.1001/archpedi.1935.01970040080010