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June 1935

TREATMENT OF INFANTILE SCURVY WITH CEVITAMIC ACID

Author Affiliations

NEW YORK
From the Department of Diseases of Children, College of Physicians and Surgeons, Columbia University.

Am J Dis Child. 1935;49(6):1441-1448. doi:10.1001/archpedi.1935.01970060045005
Abstract

In 1928 von Szent-Györgyi1 isolated a crystalline substance from plants and from the adrenal cortex of animals which he called hexuronic acid. Four years later Waugh and King2 and Svirbely and von Szent-Györgyi3 suggested that this crystalline substance was identical with vitamin C. Work in many laboratories demonstrated the correctness of their suggestion, and in 1933 von Szent-Györgyi4 renamed the substance ascorbic acid. Recently this acid (now called cevitamic acid) has been synthesized from dextrose.5 It is a white crystalline powder with active reducing properties, and its formula is C6H8O6. It is now available commercially in pure crystalline form for intravenous injection and in tablet form for oral administration. Recent biologic assays demonstrate that 20 mg. of cevitamic acid is equivalent to from 15 to 30 cc. of lemon juice.6

The present report deals with the effectiveness of cevitamic

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