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July 1935

INFLUENCE OF VIOSTEROL AND PARATHYROID EXTRACT ON MINERAL METABOLISM IN OSTEOGENESIS IMPERFECTA

Author Affiliations

MINNEAPOLIS
From the Department of Pediatrics of the University of Minnesota.

Am J Dis Child. 1935;50(1):132-157. doi:10.1001/archpedi.1935.01970070141011
Abstract

Although numerous investigators have concerned themselves with the problems of osteogenesis imperfecta, the underlying pathogenesis of this disease remains obscure, and all measures so far suggested for its treatment are admittedly quite ineffective. The study reported here deals primarily with the mineral exchanges of the body in this disorder, particularly as these exchanges are affected by such factors as the administration of parathyroid extract and of massive doses of vitamin D. The underlying purpose of the investigation was to gain some insight into the nature of this little understood disturbance in osseous development and to ascertain whether or not the well known chemical regulators of calcium and phosphorus metabolism are capable of influencing the course of the disease to any extent.

Osteogenesis imperfecta may be defined as a more or less distinct clinical entity characterized by extreme fragility and rarefaction of the bones and an abnormal bluish coloration of the

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