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November 1935

TOXICITY OF ORGANS OF ANIMALS DYING AFTER INJECTION OF EMULSIONS OF STOOLS OF PATIENTS WITH POLIOMYELITIS

Author Affiliations

CLEVELAND
From the Department of Pediatrics, Western Reserve University, and the Division of Contagious Diseases, City Hospital.

Am J Dis Child. 1935;50(5):1173-1181. doi:10.1001/archpedi.1935.01970110081011
Abstract

The experiments reported here were performed to determine (1) the toxicity of the spinal cords of guinea-pigs dying after the injection of an emulsion made of stools obtained from patients with poliomyelitis, (2) the bacteriology of the emulsions made of the spinal cords of these guinea-pigs, (3) the relative toxicity of the various emulsions made of organs obtained from normal animals and of those given injections, and (4) the bacteriology of the emulsions made of the various organs.

TOXICITY OF THE CORDS  The spinal cord was taken from a guinea-pig weighing 250 Gm. The average weight of the cord from the laryngeal cartilage to the conus was approximately 0.5 Gm. In order to secure emulsions of the spinal cord for purposes of standardization, 0.5 Gm. of cord was ground in a mortar and then emulsified in 15 cc. of physiologic solution of sodium chloride, each cubic centimeter of which contained

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